After the events of Outbreak, the club members are chased by a frenzied homicidal mob in Okinomiya. Une sees them and lets down a ladder from her window and rescues them, later allowing them to be sheltered at her house for a while. She is later referred to by Keiichi as their "saviour". The club members feel sorry for Une when they realize she is living alone and tells them that her family "hasn't returned".
Eventually Une is ushered by the club members and they take refuge at the Sonozaki Family Office, where they meet up with Hanyū and Rika again. Une is exposed by Hanyū as a godly entity similar to her— the leader of an alien strain of parasitic microorganisms that had recently arrived on earth. Hanyū communicates with her and discovers that their "roots" share the same "strength", i.e., that the parasitic strain of the Une virus was as strong as η-173. Since Class-C Brain Parasites are shown to be biologically competitive, this meant that a host can only harbor either the η-173 or the Une virus on a first come, first served basis if they were to compete. Rika quickly realizes that this meant spreading the Une virus across the globe first would curb the η-173 epidemic and proposes to have Tomitake take Une to "Tokyo" immediately and spread the virus across the suburbs.
Before they are able to execute this plan, Tamurahime no Mikoto instantly expresses her disagreement and Takano barges into the Sonozaki Family Office demanding Une to be handed over to her. As Tamura's miko, she is now armed with superhuman strength and relentlessly pursues Une despite everyone's attempt to subdue her. Hanyū uses her divine powers to momentarily weaken Takano and the club members trick her into capturing Satoko who is dressed in Une's clothes. Une is safe and she is escorted to the National Institute of Infectious Diseases and her cerebrospinal fluid is collected and sent to research facilities across the world.

Rika and Hanyū later discover that Une was originally the one Tamura wanted to stop, motivating her to spread η-173 before Une could infect anyone.
It is revealed she did so as Une's brethren were actually a strain of highly contagious killer viruses that latched onto host after host until they've depleted them of all nourishment, leaving them for dead. The Une virus soon turns into a pandemic and after seven weeks of infection, human population decreases by a whopping 20 per cent. After there are no more humans left to infect, Une will move to another inhabited plant and spread her seeds of destruction there.
Une thinks herself to be unstoppable after the outbreak, as the pandemic was now out of control and neither Hanyū nor Tamura knew where her physical body was. Rika realizes there was one way to stop Une and kills herself. This winds back time to a point before the events of Outbreak and the club members apprehend Une in Okinomiya, along with the two other gods. Having been captured before she could attempt anything, Une is distraught and confesses that she only wanted to "distribute her flowerbed a little", but Tamura's rejection had spurred her to destroy everything. Tamura, Hanyū and Une incessantly bicker and try to push the blame onto each other and it soon becomes clear that the root of all conflict was their petty rivalry. All three gods are sentenced to play games with the club members until they learn to get along with each other. Une loses her game and dons an embarrassing costume along with her fellow gods for their punishment game as they all lament the outcome and swear to get along better.